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Congestive Heart Failure

Contents
ESC 2016 Guidelines
Summary Slides
ACE Inhibitors
ARB
ARBI
Beta Blockers
Cell Transplantation
Complementary Therapy
Device
Experimental
Phosphodiesterase Inhibitors
Recombinant hBNP
Strategy
Other

ESC 2016 Guidelines

2016 ESC Guidelines for the Diagnosis and Treatment of Acute & Chronic Heart Failure:

-Summary by Dr. P. Ponikowski (ESC 2016)
-Diagnosis and New Classification by Dr. A. Voors (ESC 2016)
-Focus on Devices by Dr. F. Ruschitzka (ESC 2016)
-The Importance of Co-morbidities by Dr. S. Anker (ESC 2016)
-Prevention by Dr. L. M. Ruilope (ESC 2016)


Acute Heart Failure:

-Overview by Dr. V. Harjola (ESC 2016)
-Initial Phase in the Emergency Deptartment: Diagnosis and Management by Dr. H. Bueno (ESC 2016)
-Management of the Early Phase by Dr. J. Parissis (ESC 2016)
-Pre-Discharge Management and Criteria for Discharge by Dr. P. Ponikowski (ESC 2016)
-When Device Therapy or Intervention is Needed? by Dr. M. Jessup (ESC 2016)


Chronic Heart Failure:

-Overview by Dr. P. Nihoyannopoulos (ESC 2016)
-Management of Chronic HF: Pharmacology by Dr. G. M. C. Rosano (ESC 2016)
-Multidisciplinary Team Management by Dr. J. Riley (ESC 2016)


HFrEF:

-Devices & Interventions by Dr. J. G. F. Cleland (ESC 2016)
-How to Optimize Management by Dr. B. Pieske (ESC 2016)
-Pharmacological Treatment of HFrEF by Dr. G. M. C. Rosano (ESC 2016)


Summary Slides

Acute Heart Failure in Apical Ballooning Syndrome (Takotsubo/Stress Cardiomyopathy): Clinical Correlates and Mayo Clinic Risk Score

-Trial Overview by Dr. A. Prasad


ADHERE: Admission B-Type Natriuretic Peptide Levels and In-Hospital Mortality in Acute Decompensated Heart Failure

-Trial Overview by Dr. G. C. Fonarow


BACH Multinational Trial: Mid-Regional Pro-Adrenomedullin (MR-proADM) vs BNP and NT-proBNP as Prognosticator in Heart Failure Patients

-Trial Overview by Dr. A. Maisel (AHA 2008)


Epidemiology of CHF: Gender, age, readmission, and survival in CHF

-Epidemiology Overview


Review of the State of Heart Failure: Failure is not an option

-Literature Review by Dr. M. Jessup (AHA 2015)


ACE Inhibitors

CAMELOT: Comparison of Amlodipine vs. Enalapril to Limit Occurrences of Thrombosis

-Trial Overview by Dr. S. Nissen


CHARM: Candesartan Cilexitil in Heart Failure Assessment of Reduction Mortality and Morbidity

-Trial Overview (ESC 2003)


CONSENSUS 1: Cooperative North Scandinavian Enalapril Survival Study

-Trial Overview


ELITE II: Effects of Losartan Compared with Captopril on Mortality in Patients With Symptomatic Heart Failure

-Trial Overview by Dr. B. Pitt


EUROPA: European Trial on Reduction of Cardiac Events with Perindopril in Stable Coronary Artery Disease

-Trial Overview (ESC 2003)


HOPE: Effects of an Angiotensin-Converting Enzyme Inhibitor, Ramipril, on Death from Cardiovascular Causes, Myocardial Infarction, and Stroke in High-Risk Patients

-Trial Overview


LIFE: Losartan Intervention for Endpoint Reduction in Hypertension Study

-Trial Overview by Dr. B. Dahlöf (ACC 2002)


PEACE: Prevention of Events with Angiotensin Converting Enzyme Inhibitor (PEACE) Trial

-Trial Overview by Dr. M. Pfeffer (AHA 2004)


SOLVD: Studies of Left Ventricular Dysfunction

-Trial Overview


VALIANT: Valsartan in Acute Myocardial Infarction

-Trial Overview by Dr. M. A. Pfeffer (AHA 2003)


VHEFT 1: Effects of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure

-Trial Overview


VHEFT 2: Efficacy and Outcome with Felodipine in Heart Failure

-Trial Overview


Angiotensin Receptor Blockers (ARB)

ASTRONAUT: Effect of Aliskiren on Post-discharge Mortality and Heart Failure Readmissions Among Patients Hospitalized for Heart Failure

-1-Year Results by Dr. M. Gheorghiade (ACC 2013)


ATMOSPHERE: Direct renin inhibition with aliskiren alone, and in combination with enalapril, compared with enalapril, in heart failure

-Trial Overview by Dr. J. J. V. McMurray (ACC 2016)


I-PRESERVE Trial: Irbesartan in Heart Failure with Preserved EF

-Trial Overview by Dr. P. Carson


SUPPORT: Impact of Additive Use of Olmesartan in Patients with Chronic Heart Failure

-Trial Overview by Dr. Y. Sakata (AHA 2014)


Angiotensin Receptor-Neprilysin Inhibition (ARNI)

PARADIGM-HF: A Comparison of Angiotensin Receptor-Neprilysin Inhibition (ARNI) With ACE Inhibition in the Long-Term Treatment of Chronic Heart Failure With a Reduced Ejection Fraction

-Trial Overview by Dr. M. Packer (ESC 2014)


PARAMOUNT: The Angiotensin Receptor Neprilysin Inhibitor LCZ696 in Heart Failure with Preserved Ejection Fraction

-Trial Overview by Dr. S. D. Solomon (ESC 2012)


Beta Blockers

BB-Meta-HF: Efficacy of beta-blockers in heart failure patients with atrial fibrillation

-Trial Overview by Dr. D. Kotecha (ESC 2014)


CIBIS III: Cardiac Insufficiency Bisoprolol Study III

-Trial Overview by Dr. R. Willenheimer (ESC 2005)


COMET: Carvedilol or Metoprolol European Trial

-Trial Overview


RAFT: The Importance of Beta-Blockers in Patients with Heart Failure

-Trial Overview by Dr. L. B. Mitchell (ESC 2013)


Cell Transplantation

FOCUS-CCTRN: Effect of Transendocardial Delivery of Autologous Bone Marrow Mononuclear Cells on Functional Capacity, Left Ventricular Function, and Perfusion in Chronic Ischemic Heart Failure

-Trial Overview by Dr. E. C. Perin (ACC 2012)


MSC-HF: Stem Cells Regenerate Failing Hearts!

-Trial Overview by Dr. A. B. Mathiasen (ACC 2014)


Percutaneous Cell Transplantation of Autologous Skeletal Myoblast: Myocardial Repair by Percutaneous Cell Transplantation of Autologous Skeletal Myoblast as a Stand Alone Procedure in post-MI CHF Patients

-Trial Overview by Dr. P. W. Serruys (ACC 2005)


Complementary Therapy

CANPAP: Continuous Positive Airway Pressure for Heart Failure Patients with Central Sleep Apnea

-Trial Overview by Dr. T. D. Bradley (ACC 2005)


HF-ACTION Substudy: Effects of Exercise Training on Health Related Quality of Life in Patients with Chronic Heart Failure

-Trial Overview by Dr. K. E. Flynn


NEAT-HFpEF: Nitrate's Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction

-Trial Overview by Dr. M. M. Redfield (AHAf 2015)


VINDICATE: Favourable effects of vitamin D on cardiac function in patients with chronic heart failure secondary to left ventricular systolic dysfunction

-Trial Overview by Dr. K. Witte (ACC 2016)


Device

AATAC-AF: Ablation vs. Amiodarone for Treatment of Atrial Fibrillation in Patients with Congestive Heart Failure and an Implanted ICD/CRTD

-Trial Overview by Dr. L. Di Biase (ACC 2015)


ACORN: Assessment of a New Mesh Cardiac Support Device (CSD) in Patients with Heart Failure

-Trial Overview by Dr. D. L. Mann (AHA 2004)


ANTHEM-HF: Autonomic Regulation Therapy for the Improvement of Left Ventricular Function and Heart Failure Symptoms

-Trial Overview by Dr. I. S. Anand (ESC 2014)


ARC-HF: A Randomized Trial to Assess Catheter Ablation Versus Rate Control in the Management of Persistent Atrial Fibrillation in Heart Failure

-Trial Overview by Dr. D. G. Jones (AHA 2012)


BioPace: Biventricular Pacing for Atrio-ventricular Block to Prevent Cardiac Desynchronization

-Trial Overview by Dr. J. J. Blanc (ESC 2014)


BLOCK-HF: Biventricular versus Right Ventricular Pacing in Patients with Left Ventricular Dysfunction and Atrioventricular Block

-Preliminary Results by Dr. A. B. Curtis (AHA 2012)


DEFEAT-HF: Ventricular Functional Response to Spinal Cord Stimulation for Advanced Heart Failure

-Trial Overview by Dr. D. P. Zipes (AHA 2014)


INOVATE-HF: The Effect of Vagus Nerve Stimulation in Heart Failure

-1-Year Results by Dr. M. R. Gold (ACC 2016)


MADIT-CRT: Long-Term Survival With Cardiac Resynchronization Therapy in Mild Heart Failure Patients

-Trial Overview by Dr. I. Goldenberg (ACC 2014)


NECTAR-HF: Neurocardiac Therapy for Heart Failure

-6-Month Results by Dr. F. Zannad (ESC 2014)


OptiLink HF: Effect of implanted device-based impedance monitoring with telemedicine alerts on mortality and morbidity in heart failure

-Trial Overview by Dr. M. Böhm (ESC 2015)


PEECH: Prospective Evaluation of EECP in Congestive Heart Failure

-Trial Overview by Dr. A. M. Feldman (ACC 2005)


STITCH: Ten Year Outcome of Coronary Artery Bypass Graft Surgery Versus Medical Therapy in Patients with Ischemic Cardiomyopathy

-10-Year Results by Dr. E. J. Velazquez (ACC 2016)


Total Artificial Heart: An Evolving Role in the Management of End-Stage Heart Failure

-Overview by Dr. M. J. Slepian


VentrAssist: The VentrAssist U.S. Pivotal Bridge to Cardiac Transplantation Trial

-Overview by Dr. A. Boyle (ACC 2009)


Experimental

ATOMIC-AHF: A Phase 2 Study of Intravenous Omecamtiv Mecarbil, A Novel Cardiac Myosin Activator, In Patients With Acute Heart Failure

-Trial Overview by Dr. J. R. Teerlink (ESC 2013)


CONFIRM-HF: Effect of ferric carboxymaltose on functional capacity in patients with heart failure and iron deficiency

-Trial Overview by Dr. P. Ponikowski (ESC 2014)


COSMIC-HF: Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure

-Trial Overview by Dr. J. R. Teerlink (AHA 2015)


CUPID 2: A Phase 2b Trial Investigating the Efficacy and Safety of the Intracoronary Administration of AAV1/SERCA2a in Patients with Advanced Heart Failure

-Trial Overview by Dr. B. H. Greenberg (ESC 2015)


SOCRATES-REDUCED: The Soluble Guanylate Cyclase Stimulator Vericiguat in Worsening Chronic Heart Failure with Reduced Ejection Fraction

-Trial Overview by Dr. M. Gheroghiade (AHA 2015)


Other Pharmacotherapy

A-Heft: Impact of ISDN-hydralazine on mortality and morbidity of African-American patients with Heart Failure

-Trial Overview by Dr. A. L. Taylor (AHA 2004)


ARTS-HF: Results of ARTS-HF: Finerenone versus Eplerenone in Patients with Worsening Chronic Heart Failure and Diabetes and/or Chronic Kidney Disease

-Trial Overview by Dr. G. Filippatos (ESC 2015)


EVEREST: Efficacy of Vasopressin antagonism in hEart failuRE: outcome Study with Tolvaptan

-Trial Overview by Dr. M. A. Konstam (ACC 2007)


DIG: Digoxin Reduces 30-Day All-Cause Hospital Admission in Ambulatory Older Patients with Chronic Heart Failure and Reduced Ejection Fraction

-1-Month Results by Dr. A. Ahmed (ACC 2013)


SHIFT: Systolic Heart Failure Treatment with the Iƒ Inhibitor Ivabradine Trial

-Trial Overview by Dr. J. S. Borer (ESC 2012)


SURVIVE-W: Survival of Patients with Acute Heart Failure in Need of Intravenous Inotropic Support

-Trial Overview by Dr. A. Mebazaa (AHA 2005)


TOPCAT: Regional Variation in Patients and Outcomes in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) Trial

-Trial Overview by Dr. M. A. Pfeffer (AHA 2014)


VERITAS: Value of Endothelin Receptor Inhibition with Tezosentan in Acute Heart Failure Studies

-Trial Overview by Dr. J. J. V. McMurray (ACC 2004)


Phosphodiesterase Inhibitors

ESSENTIAL: Safety and Efficacy of Low-Dose Enoximone Therapy Among Patients with Advanced Chronic Heart Failure Already Receiving Optimal Conventional Therapy

-Trial Overview by Dr. M. Metra (ESC 2005)


RELAX-AHF: Effects of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure with Preserved Ejection Fraction

-Trial Overview by Dr. M. M. Redfield (ACC 2013)


Recombinant Human B-Type Natriuretic Peptide (hBNP)

ASCEND-HF: Acute Study of Clinical Effectivenes of Nesiritide in Decompensated Heart Failure

-Trial Overview by Dr. A. Hernandez (AHA 2010)


FUSION II: Follow-Up Serial Infusions of Nesiritide for the Management of Patients With Heart Failure

-Trial Overview by Dr. Clyde W. Yancy (ACC 2007)


PROTECT: Benefits of Natriuretic Peptide Guided Heart Failure Therapy for Patients With Chronic Left Ventricular Systolic Dysfunction

-Trial Overview by Dr. J. Januzzi (AHA 2010)


Strategy

BEAT-HF: The First-in-Man Randomized Trial of a β3-adrenoceptor Agonist in Chronic Heart Failure

-Trial Overview by Dr. H. Bundgaard (AHA 2015)


CARE-HF: Cardiac Resynchronization Heart Failure Study

-Trial Overview by Dr. J. G. Cleland (ACC 2005)


CARRESS-HF: Randomized Trial of Ultrafiltration versus Pharmacologic Care in Patients with Acute Decompensated Heart Failure and Cardiorenal Syndrome

-Trial Overview by Dr. B. A. Bart (AHA 2012)


COMPASS-CHF: Chronicle Offers Management to Patients with Advanced Signs and Symptoms of Heart Failure

-Trial Overview by Dr. R. C. Bourge (ACC 2005)


EORP: Are ambulatory patients with heart failure treated in accordance with ESC guidelines?

-Trial Overview by Dr. A. P. Maggioni (ESC 2013)


HOOPS: Pharmacist Intervention to Prevent Hospitalization and Death in Patients with Heart Failure: A Prospective Cluster Randomized Controlled Trial

-Trial Overview by Dr. R. Lowrie (AHA 2011)


IMPEDANCE-HF: Non-invasive Lung IMPEDANCE-Guided Preemptive Treatment in Chronic Heart Failure Patients

-Trial Overview by Dr. M. K. Shochat (ACC 2016)


PROSPECT: Predictors of Response to CRT

-Trial Overview by Dr. S. Ghio (ESC 2007)


ROSE-AHF: Renal Optimization Strategies Evaluation in Acute Heart Failure

-Trial Overview by Dr. H. H. Chen (AHA 2013)


SEPTAL-CRT: Comparison of right ventricular septal pacing and right ventricular apical pacing in patients receiving cardiac resynchronization therapy defibrillators

-Trial Overview by Dr. C. Leclercq (ESC 2014)


SERVE-HF: Treatment of Sleep-Disordered Breathing With Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure and Reduced Ejection Fraction

-Trial Overview by Dr. M. R. Cowie (ESC 2015)


STOP-HF: The Saint Vincents Screening to Prevent Heart Failure (STOP-HF) Study

-Trial Overview by Dr. K. McDonald (ACC 2013)


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