Antiplatelet Parenteral GPiibiiia Inhibitors

Summary

Abciximab Clinical Trial Overview

E3C Long-term mortality follow-up:  EPIC, EPILOG, EPISTENT, CAPTURE

Trials

CAPTURE Abciximab in patients with refractory unstable angina who are undergoing PTCA

EASY: A Randomized Trial of Same-day Home Discharge and Abciximab Bolus Only Compared to Overnight Hospitalization and Abciximab Bolus + Infusion after Trans-Radial Coronary Stenting

EPIC Abciximab for death, MI, and revascularization in percutaneous intervention

EPILOG Evaluation of PTCA to Improve Long-term Outcome by c7E3 GP IIb/IIIa receptor (abciximab) blockade

EPISTENT (1 Year) Randomised placebo-controlled and balloon-angioplasty controlled trial to assess safety of coronary stenting with use of platelet glycoprotein IIb/III

GUSTO IV ACS Abciximab in NSTEMI/UA patients not planned to undergo PCI

TARGET Safety and efficacy of tirofiban vs abciximab in the setting of percutaneous coronary revascularization

TARGET (6 month Results) Safety and efficacy of tirofiban vs abciximab in the setting of percutaneous coronary revascularization

Aggrastat Trials (Tirofiban) Slides

Summary

APEX Need and rationale for early treatment with GP2b3a therapy

Case Studies in the Management of ACS with GPIIbIIIa Inhibitors

Empiric Management of ACS with GPIIbIIIa Platelet Receptor Blockers

Understanding Concepts of Equivalence and Non-inferiority Trials

Trials

PRISM-Plus tirofiban and heparin in the treatment of unstable angina and non-Q-wave myocardial infarction

PRISM/RESTORE Effect of tirofiban in patients undergoing coronary interventions

TACTICS-TIMI 18 Economics and HRQOL Treat Angina with Aggrastat and determine Cost of Therapy with Invasive or Conservative Strategy

TOPSTAR 2b3a inhibition on top of aspirin, unfractionated heparin, and clopidogrel in elective PCI patients

Summary

EARLY ACS Study Design Early Eptifibatide in non-ST segment elevation ACS

Trials

CLEAR Platelets Study Eptifibatide and clopidogrel on platelet inhibition and myocardial necrosis among patients undergoing elective stenting

ELISA II Dual antiplatelet therapy with aspirin and clopidogrel compared with triple antiplatelet therapy with aspirin, clopidogrel, and tirofiban among patients with non-ST elevation myocardial infarction

ESPRIT (6 Month follow-up) Platelet Glycoprotein IIb/IIIa Integrin Blockade with Eptifibatide in Coronary Stent Intervention

ESPRIT (1 Year Results) Platelet Glycoprotein IIb/IIIa Integrin Blockade with Eptifibatide in Coronary Stent Intervention

IMPACT-2 Eptifibatide for death, MI and revascularization in percutaneous intervention

PURSUIT Eptifibatide vs placebo in a broad population of pts