Clinical Trial Results HomeCongestive Heart Failure

Summary Slides

Epidemiology of CHF  Gender, age, readmission and survival in CHF

ACE Inhibition

CAMELOT Amlodipine vs Enalapril vs Placebo in dz progression   *Source Dr. Steven Nissen, Cleveland Clinic

CHARM Candesartan in heart failure

CONSENSUS Enalapril vs. placebo for 6-month mortality in severe heart failure after MI

ELITE II Losartan vs. captopril in patients with congestive heart failure

EUROPA Treatment with perindopril vs placebo on cardiovascular events in patients with stable coronary artery disease

HOPE Effect of ACE inhibitor, Ramipril, on death, MI, stroke and diabetes

LIFE Losartan with atenolol in patients with hypertension and left ventricular hypertrophy

PEACE Prevention of Events with Angiotensin Converting Enzyme Inhibition

SOLVD Enalapril vs placebo in patients with reduced left ventricular function and congestive heart failure when added to ACE Inhibitors

VALIANT Effect of valsartan, captopril, and the combination of the two on mortality in patients with myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both

VHEFT 1 Effects of Prazosin, or combination of Hydralazine and Isosorbide dinitrate in symptomatic patients with heart failure and left ventricular dysfunction on digitalis and diuretics

VHEFT 2 Enalapril vs. hydralazine/nitrates for mortality in moderate heart failure

Other Pharmacotherapy

ACTION Nifedipine in treatment of hypertension

A-Heft Impact of ISDN-hydralazine on mortality and morbidity of African-American patients with Heart Failure

CIBIS III Bisoprolol in CHF

COMET Mortality and morbidity between the multiple adrenergic inhibitor carvedilol and the beta-1-selective agent metoprolol

ESSENTIAL safety and efficacy of low-dose enoximone therapy among patients with advanced chronic heart failure already receiving optimal conventional therapy

SURVIVE Levosimendan vs dobutamine in decompensated CHF

VERITAS Endothelin antagonism in heart failure

Mechanical

ACORN Trial of CorCap cardiac support device

CANPAP Treatment with continuous positive airway pressure (CPAP) among heart failure patients with central sleep apnea

CARE-HF Cardiac Resynchronization and Mortality

COMPASS-CHF Safety and efficacy of use of an implantable hemodynamic monitor system among patients with NYHA class III or IV heart failure

Myocardial Repair by Percutaneous Cell Transplantation of Autologous Skeletal Myoblast as a Stand Alone Procedure in post-MI CHF Patients

PEECH Enhanced external counterpulsation (EECP) among patients with systolic dysfunction, stable heart failure symptoms, and treated with optimal pharmacologic therapy