Bivalirudin: Using Movies not Words to Show the Benefits: A series of downloadable Powerpoint slide videos presented by CM Gibson.  What does binding to clot bound thrombin look like anyway?

What does it look like to be a "Direct" thrombin inhibitor, and why is that important?

What does it look like to inhibit "Clot bound thrombin", and why is it important?

What does it look like when heparin "gets distracted" and binds to heparin binding proteins while bivalirudin "stays focused" and binds to thrombin only?

Because heparin is non specific and binds to platelet factor 4, it triggers an antibody reaction that in turn is associated with HIT or heparin induced thrombocytopenia

What does it look like when heparin activates platelets and bivalirudin does not?

Why is Bivalirudin associated with less bleeding? See how it becomes inactivated when it falls off thrombin, unlike heparin which remains active

ACUITY Results

ACUITY PCI Results Presented by Dr. G Stone, TCT 2006

ACUITY Economic Results Presented by Dr. D. Cohen, TCT 2006

ACUITY Impact of Duration of Infusion < 24 hours or > 24 hours among PCI pts Presented by David Cox at TCT 2006

ACUITY Impact of Duration of Infusion < 24 hours or > 24 hours among PCI pts Presented by Charlie Pollack at AHA 2006

ACUITY Gender and Outcomes TCT 2006

ACUITY Angiographic Results TCT 2006

ACUITY Bleeding Results S. Manoukian, TCT 2006

ACUITY Bleeding Results S. Manoukian, AHA 2006

ACUITY Overall Results

ACUITY Timing Results

ACUITY Transfusion Results S. Manoukian, TCT 2006

ACUITY Diabetic Results F Feit, AHA 2006

ACUITY Elderly Results K Alexander, TCT 2006