ST Elevation MI: Fibrinolysis

Fibrinolytic Monotherapy:

ASSENT 2 TNK in STEMI

ASSENT-3 TNK in STEMI

ASSENT 3-PLUS Low molecular weight heparin enoxaparin vs unfractionated heparin in combination with TNK for STEMI

ASSENT 4 Assessment of the Safety and Efficacy of a New Treatment Strategy for Acute Myocardial Infarction

CLARITY-TIMI 28 Largest Angiographic ST Elevation MI Trial to Date Shows Improved Patency & Myocardial Perfusion with Plavix

COMMIT Clopidogrel Clopidogrel vs placebo among patients with ST elevation myocardial infarction (MI) also treated with aspirin

COMMIT Lopressor Treatment with the beta-blocker metoprolol compared with placebo among patients with STEMI also treated with aspirin

CREATE-Reviparin Trial of low molecular wt. heparin oid in STEMI

ENTIRE Phase 2 study of Enoxaparin in STEMI

EXTRACT-TIMI 25 Enox vs UFH in 20,000 STEMI pts provided by Dr. Elliott M. Antman

HART 2 Enoxaparin in STEMI

TIMI 10A, 10B, ASSENT I TNK in STEMI

Half Dose Fibrinolytic + Full Dose GPIIbIIIa inhibition:

FASTER Aggrastat in STEMI

GUSTO 5 trial design  rPA + abciximab vs rPA alone in STEMI

INTEGRITI Eptifibatide + TNK in STEMI

INTRO AMI Rationale Eptifibatide + lysis in STEMI

INTRO AMI Results Eptifibatide + lysis in STEMI

SPEED rPA + abciximab

TIMI 14 rPA + abciximab in STEMI

Facilitated PCI:

ADMIRAL Abciximab pre-PCI for STEMI

ADVANCE Additive value of tirofiban administered with the high-dose bolus in the prevention of ischemic complications during high-risk coronary angioplasty *Provided by Dr. Valgimigli, University of Ferrara Italy & Erasmus MC, the Netherlands

CADILLAC vs ADMIRAL

CAPITAL AMI Combined Angioplasty and Pharmacological Intervention Versus Thrombolytics Alone in Acute Myocardial Infarction

GRACIA-2 Safety and efficacy of optimal primary PCI vs facilitated PCI with TNK+stenting in patients with ST elevation MI

INTAMI Integrilin in Acute Myocardial Infarction

PACT Half dose tPA before PCI in STEMI

REACT Rescue Angioplasty Versus Conservative Therapy or

Repeat Thrombolysis Trial

STRATEGY Single High-Dose Bolus Tirofiban and Sirolimus-Eluting Stent vs. Abciximab and Bare-Metal Stent in Myocardial Infarction

TETAMI Treatment of Enoxaparin and Tirofiban in Acute Myocardial Infarction

TIGER PA Aggrastat before primary PCI